Your first choice is to move.
Second choice is to make it look looted or of no value.
There is no defending a house with that many people around even if only an extreme minority want what you have.
If money was no object you could armor the walls, razor tape etc but if you are the only game in town they will get in or burn you out. Going through that much trouble though you're better off in a tent in the woods where there are no people.
Your strongest defensive weapon is to remain low key and of no value. If there has been no electric for a month and your house is lit like a Christmas tree with loud music playing there will be a line of people wondering why you have what want. If they can't have it they will die trying to make sure you don't have it either.
Depending on what you want to defend it against, if it is a total SHTF situation eventually smart people will be going house to house in an orderly fashion looking for supplies. Not all will be bad people. It would be foolish for you to not do the same and potentially lose valuable assets.