Taking the High Road
One of the most critical factors is route planning. You should have memorized several routes to your safe house or survival retreat and have maps on hand so you can identify alternate routes around accidents or other problem areas. The routes should include:
The fastest, most direct route.
This will be your first choice when you are getting out early, before the crowds. If you're smart enough to beat the rush, predict an upcoming disruption, or just feel like being far away from any federal buildings on every April 19, you can take your main route.
A back road route.
This may be your best bet when the interstates are clogged with lines of cars all trying to leave "ground zero." Sure, it would normally take longer, but it in this situation, it may be your best bet.
An indirect route.
There may be a time when you need to get away, but don't want anyone to know where you're going. There may come a day when it make sense to go north 200 miles out of your way to end up 150 miles east of your destination. This is also the route to choose if you have reason to believe you may be followed.