Now lets look at the bad side

Safehouses can be compromised without you even knowing that they are compromised. Then the question is what priority level are the new residents? Is it a single parent on the run over some custody issue? Then it might not be worth a raid by the full force of the government. If it is the crew that just blew up a federal building, well, then you might have a problem.

Scott Woodring - His location was betrayed (for money) by safehouse hosts. Their situation was apparently to give travelers access to vehicles to sleep in (vans or campers) and general access to an outbuilding of some sort for facilities. They used high security measures for phone and mail. Woodring did not have a chance once the vehicle he was sleeping in was surrounded. There has been no known retaliation against the safehouse "hosts".

Eric Rudolf - Was rumored and is strongly believed to have utilized several safehouses during his bombing campaign and his years as a fugitive. Rudolf has maintained that he did not use safehouses, but had simply relied on his wilderness survival skills.

Timothy McVeigh and his bank robbery crew the "Aryan Resistance Army" had apparently used several safehouses in and around Elohim City in Oklahoma with varying degrees of success. Several had been compromised, but apparently not raided as the feds were concentrating efforts on what they thought were broader cases at the time. This most likely involved suspected drug smuggling since Elohim city had an uncharacteristically large private runway capable of servicing small jets and larger prop driven aircraft. McVeigh was most likely betrayed by safehouse hosts (or the host organization) in one fashion or another. Most of the rest of the ARA were quickly rounded up and killed or imprisoned for life.